| NBA | SPURS |
| DÍA | SAS | LOCAL | RES | VISITANTE | GINÓBILI |
| 25-10-2016 | 1-0 | GSW | 100-129 | SAS | 10p-5re-2as-1ro-20m52 |
| 27-10-2016 | 2-0 | SAC | 94-102 | SAS | 8p-3re-5as-19m22 |
| 29-10-2016 | 3-0 | SAS | 98-78 | NOP | (descanso) |
| 30-10-2016 | 4-0 | MIA | 99-106 | SAS | 4p-6re-2as-2ro-27m30 |
| 01-11-2016 | 4-1 | SAS | 91-106 | UTA | 8p-1re-3as-1ro-23m07 |
| 04-11-2016 | 5-1 | UTA | 86-100 | SAS | 9p-3re-1pe-14m07 |
| 05-11-2016 | 5-2 | SAS | 92-116 | LAC | 7p-4re-1a-12m53 |
| 09-11-2016 | 5-3 | SAS | 99-101 | HOU | 8p-1re-3a-2ro-20m50 |
| 11-11-2016 | 6-3 | SAS | 96-86 | DET | 10p-1re-1a-1ro-16m01 |
| 12-11-2016 | 7-3 | HOU | 100-106 | SAS | 12p-2re-3a-15m31 |
| 14-11-2016 | 8-3 | SAS | 94-90 | MIA | 6p-4re-2a-16m59 |
| 16-11-2016 | 9-3 | SAC | 105-110 | SAS | 2p-1re-2a-2ro-16m00 |
| 18-11-2016 | 10-3 | LAL | 107-116 | SAS | 10p-3as-1ta-21m20 |
| 21-11-2016 | 11-3 | SAS | 96-91 | DAL | 8p-3re-4a-3ro-24m41 |
| 23-11-2016 | 12-3 | CHA | 114-119 | SAS | 5p-3re-2a-2ro-16m08 |
| 25-11-2016 | 13-3 | BOS | 103-109 | SAS | 3p-2re-2a-21m44 |
| 26-11-2016 | 14-3 | WAS | 100-112 | SAS | (descanso) |
| 29-11-2016 | 14-4 | SAS | 83-95 | ORL | 13p-6re-3a-2ro-22m31 |
| 30-11-2016 | 15-4 | DAL | 87-94 | SAS | (descanso) |
| 02-12-2016 | 16-4 | SAS | 107-105 | WAS | 13p-1re-7a-3ro-24m |
| 05-12-2016 | 17-4 | MIL | 96-97 | SAS | 6p-2re-1a-4ro-20m39 |
| 06-12-2016 | 18-4 | MIN | 91-105 | SAS | (descanso) |
| 08-12-2016 | 18-5 | CHI | 95-91 | SAS | 2re-2a-1ro-1ta-18m21 |
| 10-12-2016 | 19-5 | SAS | 130-101 | BKN | 3p-1re-3a-2ro-17m |
| 14-12-2016 | 20-5 | SAS | 108-101 | BOS | 12p-2re-4a-1ro-21m34 |
| 15-12-2016 | 21-5 | PHO | 92-107 | SAS | 2p-1re-3a-2ro-15m18 |
| 18-12-2016 | 22-5 | SAS | 113-100 | NOP | 17p-1re-1a-1ro-1ta-17m32 |
| 20-12-2016 | 23-5 | HOU | 100-102 | SAS | 12p-4re-3a-3ro-19m00 |
| 22-12-2016 | 23-6 | LAC | 106-101 | SAS | (descanso) |
| 23-12-2016 | 24-6 | POR | 90-110 | SAS | (descanso) |
| 25-12-2016 | 25-6 | SAS | 119-110 | CHI | 3p-2re-3a-1ta-19m51 |
| 28-12-2016 | 26-6 | SAS | 119-98 | PHO | 12p-5re-3a-2ro-3ta-19m33 |
| 30-12-2016 | 27-6 | SAS | 110-94 | POR | 14p-7re-2a-17m04 |
| 01-01-2017 | 27-7 | ATL | 114-112 | SAS | 10p-3re-3a-2ro-20m45 |
| 03-01-2017 | 28-7 | SAS | 110-82 | TOR | 4p-1re-2a-17m45 |
| 05-01-2017 | 29-7 | DEN | 99-127 | SAS | 11p-3re-3a-1ro-1ta-18m18 |
| 07-01-2017 | 30-7 | SAS | 102-85 | CHA | 3p-2re-4a-1ro-1ta-20m59 |
| 10-01-2017 | 30-8 | SAS | 107-109 | MIL | 3p-1re-1a-14m49 |
| 12-01-2017 | 31-8 | SAS | 134-94 | LAL | 2p-9m15 |
| 14-01-2017 | 31-9 | PHO | 108-105 | SAS | 16p-2re-3a-25m06 |
| 17-01-2017 | 32-9 | SAS | 122-114 | MIN | 9p-2re-2a-1ro-19m33 |
| 19-01-2017 | 33-9 | SAS | 118-104 | DEN | 14p-5re-4a-3ro-20m23 |
| 21-01-2017 | 34-9 | CLE | 115-118 | SAS | 8p-2re-3a-19m54 |
| 23-01-2017 | 35-9 | BKN | 86-112 | SAS | (espalda) |
| 24-01-2017 | 36-9 | TOR | 106-108 | SAS | 8p-1a-1ro-22m09 |
| 27-01-2017 | 36-10 | NOP | 119-103 | SAS | 7p-4a-1ro-15m29 |
| 29-01-2017 | 36-11 | SAS | 101-105 | DAL | 10p-5re-3a-1ro-23m47 |
| 31-01-2017 | 37-11 | SAS | 108-94 | OKC | 8p-2re-4a-1ro-1t-20m33 |
| 02-02-2017 | 38-11 | SAS | 102-86 | PHI | 2p-3re-2a-1ro-9m05 |
| 04-02-2017 | 39-11 | SAS | 121-97 | DEN | 18p-1re-1ro-10m07 |
| 06-02-2017 | 39-12 | MEM | 89-74 | SAS | 12p-3a-1ro-17m10 |
| 08-02-2017 | 40-12 | PHI | 103-111 | SAS | 3p-2a-1ro-17m59 |
| 10-02-2017 | 41-12 | DET | 92-103 | SAS | 3p-2re-2a-1ro-1t-17m29 |
| 12-02-2017 | 41-13 | NYK | 94-90 | SAS | 4p-3re-4a-1ro-17m02 |
| 13-02-2017 | 42-13 | IND | 106-110 | SAS | 2p-10m33 |
| 15-02-2017 | 43-13 | ORL | 79-107 | SAS | 2p-2re-2a-15m45 |
| 24-02-2017 | 44-13 | LAC | 97-105 | SAS | 6p-3re-4a-3ro-22m18 |
| 26-02-2017 | 45-13 | LAL | 98-119 | SAS | 6p-4a-2ro-20m |
| 01-03-2017 | 46-13 | SAS | 100-99 | IND | 9p-1re-22m59 |
| 03-03-2017 | 47-13 | NOP | 98-101 | SAS | 5p-3re-2a-20m49 |
| 04-03-2017 | 48-13 | SAS | 97-90 | MIN | (descanso) |
| 06-03-2017 | 49-13 | SAS | 112-110 | HOU | 9p-3re-2a-1ro-20m26 |
| 08-03-2017 | 50-13 | SAS | 114-104 | SAC | 19p-4re-5a-3ro-25m27 |
| 09-03-2017 | 50-14 | OKC | 102-92 | SAS | (descanso) |
| 11-03-2017 | 51-14 | SAS | 107-85 | GSW | 6p-5re-6a-18m49 |
| 13-03-2017 | 52-14 | SAS | 107-99 | ATL | 3p-4re-6a-2ro-22m44 |
| 15-03-2017 | 52-15 | SAS | 106-110 | POR | 7p-1re-6a-2ro-19m46 |
| 18-03-2017 | 52-16 | MEM | 104-96 | SAS | 5p-1a-1ta-16m04 |
| 19-03-2017 | 53-16 | SAS | 118-102 | SAC | (descanso) |
| 21-03-2017 | 54-16 | MIN | 93-100 | SAS | 11p-3re-2a-3ro-19m28 |
| 23-03-2017 | 55-16 | SAS | 97-90 | MEM | 6p-2re-3a-2ro-18m30 |
| 25-03-2017 | 56-16 | SAS | 106-98 | NYK | 4p-1re-4a-3ro-19m |
| 27-03-2017 | 57-16 | SAS | 103-74 | CLE | 12p-3re-1a-1ro-16m54 |
| 29-03-2017 | 57-17 | SAS | 98-110 | GSW | 6p-1re-3a-2ro-17m |
| 31-03-2017 | 58-17 | OKC | 95-100 | SAS | 8p-4re-8a-1ta-26m49 |
| 02-04-2017 | 59-17 | SAS | 109-103 | UTA | (descanso) |
| 04-04-2017 | 60-17 | SAS | 95-89 | MEM | 1re-6m13 |
| 05-04-2017 | 60-18 | SAS | 95-102 | LAL | (cuádriceps derecho) |
| 07-04-2017 | 61-18 | DAL | 89-102 | SAS | (cuádriceps derecho) |
| 08-04-2017 | 61-19 | SAS | 87-98 | LAC | 3p-4re-2a-21m |
| 10-04-2017 | 61-20 | POR | 98-99 | SAS | 11p-1a-16m |
| 12-04-2017 | 61-21 | UTA | 101-97 | SAS | 5p-2re-2a-1ro-18m |
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